Penn State vs Ohio State prediction and analysis

October 31, 2025
CFB Predictions
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Matchup Overview

The Penn State Nittany Lions (3-4) are set to face the undefeated Ohio State Buckeyes (7-0) on November 1, 2025, at 12:00 PM EDT. Ohio State enters the game as a heavy favorite, with a betting line of -19.5 and an over/under set at 44.5 points. This clash pits a resilient, but underdog Penn State squad against a dominant Ohio State team boasting one of the nation’s most formidable home records.

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Key Factors Influencing the Game

  • Home Field Advantage: Ohio State’s remarkable performance at home in this scenario cannot be overstated. The Buckeyes have won 57 of their last 58 home games against non-AP-ranked opponents, underscoring the challenge for Penn State.
  • Recent Trends in Betting and Performance: Penn State has historically struggled as an underdog, losing each of their last 11 games in such a role. Conversely, Ohio State has covered the spread in 10 of its last 11 games as a favorite, indicating strong consistency when expected to win decisively.
  • November Performance: While Penn State has a good record in November overall, winning six of their last seven games, they have a less favorable record against top-15 teams and in covering spreads during this month.
  • Defensive Highlights: Penn State’s Arvell Reese has been a defensive force, recording at least one sack in three consecutive games. Ohio State’s defense is particularly stout in the second and fourth quarters, allowing the fewest points nationally in those periods.
  • Offensive Tendencies: Penn State’s offense, led in receptions by Trebor Pena (23 catches this season), will be challenged to break through a Buckeyes defense that limits scoring effectively late in games.
  • Unders Reflecting Defensive Battles: Both teams tend to play in games that finish under the total points line, particularly in November games involving top-ranked teams or Ohio State as a favorite, suggesting this might be a defensively controlled contest.

Prediction Summary

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Given Ohio State’s dominance at home, their historical consistency against teams like Penn State, and their ability to stifle scoring in crucial quarters, they look well poised to control this game. Penn State’s recent success in November provides some optimism, but the Buckeyes’ firepower and defensive prowess should prevail.

The anticipated outcome is an Ohio State victory by a margin close to the spread. The game is likely to be a low-to-moderate scoring affair, reflecting the defensive strengths on both sides.

Final Prediction

Ohio State -19.5