Indianapolis Colts vs San Francisco 49ers prediction and analysis

Game Info San Francisco 49ers (10-4) at Indianapolis Colts (8-6) — Monday, Dec. 22, 2025, 8:15 p.m. ET at Lucas Oil Stadium. Current market: Colts +5.5, Total 46.5. Recommended Sports Betting Sites Quick Narrative The 49ers arrive with momentum after a multi-game winning streak and a physical identity on defense; the Colts are trying to […]








