Colts vs Jaguars prediction and analysis

December 26, 2025
NFL Betting Predictions
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Game Overview

The Jacksonville Jaguars (11-4) visit the Indianapolis Colts (8-7) at Lucas Oil Stadium on Sunday, December 28. Jacksonville arrives on a long winning run and a high-octane offense led by Trevor Lawrence and a deep receiving corps. Indianapolis is sputtering defensively and has dropped multiple games in a row, but still possesses playmakers on offense, including Jonathan Taylor in the backfield. The betting line lists the Colts as +6.5 underdogs with an over/under near 48.5.

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Key Context & Recent Form

Jaguars: Jacksonville has been one of the NFL’s hottest teams, stringing together wins with explosive scoring and balance. Trevor Lawrence has been efficient, and the Jaguars’ receiving depth forces defenses to cover the entire field. Their defense has also tightened in recent weeks, creating turnovers at timely moments and limiting opponents in the red zone.

Colts: Indianapolis has struggled to contain big plays and has given up large point totals recently. While Philip Rivers (or the current Colts starter) has managed enough offensively to move the ball at times, the Colts defense has allowed sustained drives and been attackable in the secondary. Jonathan Taylor remains a potent threat on the ground and is the centerpiece of the Colts’ offensive plan.

Matchups That Matter

  • Jaguars pass rush vs. Colts offensive line — Jacksonville’s front needs to generate pressure to limit Rivers’ time to find intermediate targets and to force mistakes. If the Jaguars win the line-of-scrimmage battle, Indianapolis will struggle to sustain drives.
  • Colts run game vs. Jaguars linebackers — Jonathan Taylor can flip a game if he gets downhill lanes. The Colts should lean on him to control the clock and keep Trevor Lawrence off the field. How well Jacksonville’s linebackers and safeties fill gaps will determine if Taylor can produce a long, game-changing day.
  • TREY receivers vs. Colts secondary — Jacksonville’s rotation of pass-catchers creates matchup problems. If Indianapolis cannot match up with speed and size across the formation, Lawrence will find favorable targets in critical situations.

Situational Trends & Edges

  • Jacksonville has momentum and a recent head-to-head win over Indianapolis, which gives them psychological and schematic edges.
  • Indianapolis has lost several straight games and appears vulnerable after surrendering big totals to high-powered offenses.
  • Home-field advantage helps the Colts, but trends show favorites have handled the Colts at Lucas Oil recently.

Betting Angles

The number around 6.5 points puts the Jaguars in a comfortable position for bettors who believe Jacksonville’s offense will control tempo and that the Colts’ defense will continue to allow chunk plays. The total near 48.5 reasonably reflects both teams’ recent scoring — if the Colts lean heavily on Jonathan Taylor to chew clock and the Jaguars manage efficient second-half play, the game can stay under. Conversely, if Jacksonville’s passing attack gets rolling early, this clears the over boundary quickly.

Prediction Summary

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Given the Jaguars’ sustained hot streak, the mismatch in defensive consistency, and Jacksonville’s clear ability to create explosive plays in all three levels of the offense, the Jaguars are positioned to win this matchup by a comfortable margin. Indianapolis will make it competitive early — expect Jonathan Taylor to find some success — but Jacksonville’s superior passing attack and playmaking will break the game open in the second half.

Final Take

Projection: Jacksonville 31, Indianapolis 20 — Jaguars win by 11 points. On the spread, I’m siding with Jacksonville to cover — take the Jaguars -6.5. For total players, consider a lean toward the under if you expect the Colts to emphasize the run and slow the clock; take the over only if you believe Indianapolis will be forced into a shootout early.

Prediction: Jacksonville Jaguars -6.5