Cardinals vs Seahawks prediction and analysis

Game Overview

The Arizona Cardinals visit the Seattle Seahawks on Sunday, November 9 (4:05 p.m. ET). The market currently lists Seattle as a 6.5-point favorite with a 45.5 over/under. On paper this looks like a classic divisional mismatch: a top-5 offense-and-defense Seahawks squad hosting a rebuilding Cardinals team that has struggled to maintain consistency.

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Seattle Seahawks Breakdown

The Seahawks enter this game sitting atop the NFC West with a 6-2 record. Their attack is balanced and efficient — averaging roughly 29 points per game — while the defense has been stingy, allowing fewer than 19 points per game. Key contributors include QB Sam Darnold (high completion rate and steady touchdown production), RB Kenneth Walker III in the ground game, and WR Jaxon Smith-Njigba, who has emerged as a top receiving threat. Seattle also boasts a pass rush and takeaways combination that ranks among the league leaders, which flips field position and creates scoring chances.

Arizona Cardinals Breakdown

Arizona is 3-5 and has shown flashes — including a recent road win — but the overall profile is uneven. The Cardinals are averaging about 22.5 points per game and surrendering roughly 21.4, making them middle of the pack on both sides. Kyler Murray is the clear playmaker when healthy and effective, and the receiving corps has capable hands. However, the offensive line and run game inconsistencies, plus a defense susceptible to explosive plays, leave them vulnerable against disciplined, opportunistic teams.

Key Matchups and Factors

• Offensive line vs. pass rush: If Seattle’s front seven can pressure Kyler and disrupt timing, Arizona will struggle to sustain drives.
• Kenneth Walker vs. Arizona front: Walker’s ability to earn chunk yards sets the tone. He’s had success in this matchup historically.
• Jaxon Smith-Njigba vs. Cardinals secondary: Smith-Njigba’s route running and yards-after-catch potential can stress Arizona’s coverage schemes.
• Turnover battle: Seattle’s defense ranks highly in sacks and interceptions — creating turnovers will be pivotal for Seattle to control field position and pace.
• Home-field trends: Seattle has dominated this series recently; momentum and crowd noise at Lumen Field compound the Cardinals’ uphill climb.

Betting Context

The line sits around Seahawks -6.5 with an O/U of 45.5. Historically the Seahawks have covered against Arizona in recent seasons and many of their meetings have skewed under the total. Seattle is also 4-0 on the road this season, but 2-2 at home — an odd split that deserves a small caution flag. Arizona has covered a number of underdog spots lately and plays tougher than their record suggests on the road.

In-Game Scenarios to Watch

• If Seattle wins the turnover battle and controls the tempo with Walker, the game becomes a manageable clock-control win for the home team.
• If Arizona hits chunk plays early via Kyler’s mobility or defensive takeaways, the Seahawks could be forced into a more aggressive passing approach that increases variance.
• Weather and in-game injuries could swing the spread; monitor pregame statuses for key starters on both lines.

Prediction Summary

Seattle’s combination of a top-5 offense, a high-performing defense and a favorable recent track record versus Arizona makes them the logical choice here. The Seahawks should be able to generate pressure, limit explosive plays from the Cardinals, and convert short fields into points. Arizona has weapons and will make this competitive at times, but the talent gap and matchup dynamics favor Seattle covering a touchdown.

Final call: Take the Seattle Seahawks -6.5. Expect a controlled Seattle victory in the neighborhood of 10–13 points in a game that likely stays below the posted total.

Prediction: Seattle Seahawks -6.5