Broncos vs Bills prediction and analysis

Game Overview
This AFC Divisional Round clash pits the 14-3 Denver Broncos against the 12-5 Buffalo Bills at Mile High Stadium. The market opened with Denver as a narrow favorite (Broncos -1.5) and an implied total around 45.5. The matchup stacks Denver’s dominant pass rush and stifling home defense against Buffalo’s top-tier running attack and an elite dual-threat quarterback in Josh Allen.
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Key Factors and Trends
- Broncos pass rush: Denver led the league in sacks during the regular season and brings a deep, rotational front capable of creating pressure without heavy reliance on one star pass rusher. That defensive identity will be pivotal against Buffalo’s offensive line and Josh Allen’s tendency to extend plays.
- Bills ground game: James Cook finished the regular season as the NFL’s leading rusher and gives Buffalo a reliable way to control tempo, shorten the game, and limit Denver possessions. How well the Bills establish Cook early will shape playcalling and clock management.
- Quarterback matchups: Bo Nix has been efficient and has helped Denver win tight games, but his protection and decision-making under pressure will be tested. Josh Allen, even if not 100%, still creates big-play potential with arm and legs; Denver must limit explosive plays to win.
- Home-field edge and recent form: Denver has been exceptional this season (13 wins in their last 14), particularly strong at home in close games. Conversely, Buffalo has struggled historically in road postseason games, which is a real handicap in a hostile Mile High environment.
Matchups to Watch
- Broncos front seven vs. James Cook: If Denver can slow Cook and force Buffalo to rely on Allen for consistent drives, the Broncos gain a strategic advantage.
- Edge rushers vs. Bills tackles: Winning on the edges will determine whether Allen has clean pockets to pick apart Denver’s secondary.
- Broncos secondary vs. Bills receiving corps: Denver’s coverage units are opportunistic — limiting chunk plays from Brandin Cooks and other perimeter threats will be essential.
Why Denver Wins
- Elite pass rush that can disrupt Allen’s timing and force turnovers or poor throws.
- Consistent home performances and an ability to win low-variance, tight games.
- Defensive versatility — they can clamp down in the red zone and bottle up second-level opportunities.
Why Buffalo Can Pull the Upset
- James Cook’s rushing can dominate time of possession and keep Denver’s offense off the field.
- Josh Allen’s big-play upside — a couple of explosive plays can flip field position and scoring quickly.
- Buffalo’s offensive balance and creativity on play-action against aggressive fronts could create favorable matchups.
Game Script and Betting Angle
Expect a physical, possession-oriented game early with Denver trying to manufacture pressure and Buffalo aiming to run Cook and control the clock. If the Broncos generate consistent third-down stops and early sacks, they’ll win by forcing Buffalo into uncomfortable down-and-distance situations. Conversely, if Buffalo sustains long drives and keeps Denver’s defense on the field, the Broncos’ offense could be limited.
Final Prediction
My read: Denver’s defensive identity and home-field edge are the decisive factors. Buffalo’s rushing attack is a real weapon, but the Broncos’ front is designed to negate that and make Allen beat them under duress. I like Denver in a close, lower-scoring game — the Broncos win a tight contest at Mile High.
Prediction: Denver Broncos 23, Buffalo Bills 17 — take the Broncos moneyline (Broncos ML) and consider the Under 46 as a secondary play.