UCLA vs Ohio State prediction and analysis

November 10, 2025
CFB Predictions
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Team Overview and Key Stats

The upcoming Week 12 showdown pits the UCLA Bruins against the Ohio State Buckeyes. Both teams bring contrasting strengths and weaknesses to the field, setting the stage for an intriguing matchup.

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UCLA Bruins have an emerging offensive threat in quarterback Julian Sayin, who has impressively thrown for over 300 yards in three straight games. This streak ties for the longest active run in the FBS, indicating a hot hand and lethal passing capability. However, UCLA’s defense faces challenges, especially against the run. They currently rank near the bottom nationally—124th—in rushing yards allowed per game, conceding an average of 191.1 yards on the ground. Additionally, they struggle to start strong, ranking 127th in average first-quarter point differential at -5.3, which may put early pressure on the offense.

On the other hand, Ohio State Buckeyes boast one of the most formidable defenses in the country. Leading the FBS in fewest opponent points allowed in both the first half (3.2 points per game) and second half (4.0 points per game), their defense stifles opponents consistently throughout the game. Offensively, they have a reliable receiving threat in Anthony Woods, who ranks tied for first in the Big Ten in catch rate (89.5%) among qualified players, showcasing his efficiency and sure hands.

Matchup Analysis

  • Quarterback vs. Defense: Julian Sayin’s recent passing success will be put to the test against an Ohio State defense known for early and sustained suppression of opponent scoring.
  • Rushing Attack: Given UCLA’s difficulties in run defense, expect Ohio State to lean on their ground game to exploit this weakness, potentially controlling the clock and momentum.
  • Early Game Dynamics: UCLA’s tendency to start slowly could allow Ohio State to build an early lead and dictate the pace, forcing UCLA to play catch-up.
  • Key Players: Watch for Anthony Woods as a reliable security blanket for Ohio State QB, maximizing high-percentage receptions that keep drives alive.

Prediction Summary

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Ohio State’s top-ranked defense combined with their efficient offense and UCLA’s defensive vulnerabilities make the Buckeyes clear favorites in this clash. Unless UCLA’s offense can overcome the stout pass rush and strong secondary, Ohio State is positioned to limit scoring opportunities and capitalize on UCLA’s defensive lapses.

Expect Ohio State to assert dominance early, clamping down on UCLA’s run game and putting pressure on Sayin to force mistakes. The Bruins’ recent passing success may keep the scoreboard respectable, but the Buckeyes should control the tempo and secure a comfortable win.

Final Prediction: Ohio State Buckeyes win by 21 points or more.