Syracuse vs Notre Dame prediction and analysis

November 20, 2025
CFB Predictions
...

Matchup Overview

The upcoming clash between the Syracuse Orange and the Notre Dame Fighting Irish promises to be an intriguing battle rooted in historical trends and current season dynamics. Notre Dame enters this contest with a formidable record at home, especially in November, while Syracuse struggles historically on the road against highly ranked foes during this time of year.

Recommended Sports Betting Sites

100% up to $750
50% up to $200
100% up to $200

Key Historical and Statistical Factors

  • Notre Dame’s November Dominance at Home: The Fighting Irish have won 15 straight November games at Notre Dame Stadium, showcasing their December resilience and home-field advantage.
  • Syracuse’s November Woes: With 10 losses in 11 November contests against AP-ranked teams, Syracuse faces an uphill battle, particularly away from home.
  • Spread Performance: Notre Dame has successfully covered the spread in their last 11 home games against ACC opponents, demonstrating consistent superiority. Conversely, Syracuse has failed to cover in 9 of their last 11 November road fixtures.

Scoring Trends and Defensive Strengths

  • Past meetings between Syracuse and ranked teams have tended to produce high-scoring affairs, with Syracuse’s last four against AP-ranked teams going over the total points line.
  • Notre Dame’s recent November games at home have similarly trended over, with five of six contests exceeding the expected total.
  • Defensively, Notre Dame is a shutdown team in the fourth quarter, ranking 3rd nationally in limiting opponent points (2.9 per game), as well as 3rd in interceptions (17), stifling late-game comebacks.
  • On the other side, Syracuse ranks near the bottom of FBS in third quarter scoring (3.3 points) and struggles significantly in second quarter point differential (-5.0), indicating offensive struggles and possible vulnerability midgame.

Prediction Summary

Bovada

5.0/5
100% up to $750

Considering Notre Dame’s dominance at home in November, both historically and this season, and Syracuse’s notable difficulties scoring and covering spreads against quality competition on the road, this game is expected to lean heavily in favor of the Fighting Irish. The strong Notre Dame defense, particularly in clutch moments of the fourth quarter, should quell Syracuse’s offense, while the Irish’s own attack will likely capitalize on Syracuse’s second and third-quarter inefficiencies.

Final Prediction: Notre Dame to win convincingly and cover the spread at home against Syracuse.