South Carolina vs LSU prediction and analysis

October 6, 2025
CFB Predictions
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Game Overview

On October 11, 2025, the South Carolina Gamecocks (3-2) will visit the LSU Tigers (4-1) at Tiger Stadium for a high-stakes SEC battle kicking off at 7:45 PM EDT. LSU enters favored by 10 points, with the over/under set at 44.5 points, reflecting expectations for a moderately high-scoring game.

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Team Form and Key Considerations

  • LSU Tigers: Sitting at 4-1, LSU has shown strong form on both sides of the ball, particularly leveraging their home-field advantage. Their offense has been efficient and explosive at times, and their defense remains stout against the run and pass. LSU’s ability to control tempo and capitalize on turnovers has been a theme this season.
  • South Carolina Gamecocks: With a 3-2 record, South Carolina has been competitive but inconsistent. Their offense has faced some challenges generating consistent yardage, and defensive lapses have cost them in key moments. However, the Gamecocks have shown resilience and can surprise stronger teams if they manage to execute well.
  • Matchup Issues: LSU’s physical front seven will test South Carolina’s offensive line, which has struggled to create clean pockets for the quarterback. Conversely, South Carolina’s defense will need to find ways to disrupt LSU’s rhythm, especially limiting big plays from LSU’s skill positions.

Betting and Player Trends

LSU’s 10-point favoritism is reflective of their strong home advantage and superior depth. The over/under of 44.5 suggests a moderately paced game with both defenses making critical stops. Betting trends favor LSU at home, and player performances, particularly at quarterback and linebacker positions, will be pivotal.

Prediction Summary

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The LSU Tigers are poised to extend their winning momentum with a calculated victory over South Carolina. While the Gamecocks have shown they can compete physically, LSU’s balanced offense and tenacious defense, combined with the home crowd support, create a difficult environment for South Carolina. Expect LSU to cover the spread by controlling the line of scrimmage and limiting South Carolina’s explosive opportunities.

Final Prediction

LSU to win by 10-14 points, covering the -10 spread.