SMU vs Missouri State prediction and analysis

September 11, 2025
CFB Predictions
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Game Overview

The SMU Mustangs (1-1) are set to face off against the Missouri State Bears (1-1) on September 13, 2025, with kickoff scheduled for 3:30 PM EDT. The betting line currently favors SMU heavily, with Missouri State as a +27.5 underdog, and the Over/Under set at 61.5 points. This game presents a compelling crowd for bettors and fans alike, as both teams have experienced a mixed start to their season.

SMU’s Recent Performance and Trends

  • Conference Success: SMU holds a strong record against teams from Conference USA, having won their last five encounters. This suggests the Mustangs perform well against familiar regional opposition.
  • Covering the Spread: Despite some recent losses, SMU has been competitive in their games post-overtime, covering the spread in three of their last four contests following overtime matches.
  • Road Issues: One notable weakness for SMU is their performance in road openers—they have failed to cover the spread in four of their past five away season openers, pointing to potential sluggish starts away from home.

Missouri State’s Outlook

The Bears enter this game at 1-1 without a significant advantage in history or betting trends. While the betting odds are not in their favor, Missouri State’s performance could be unpredictable based on which team shows up on game day. Missouri State has yet to establish a strong offensive or defensive identity this season, which makes their competitiveness difficult to gauge.

Key Matchup Factors

  • Offensive Firepower: SMU’s offense typically operates at a higher tempo and with more efficiency than Missouri State’s, which could dictate the game’s pace.
  • Defensive Stability: Missouri State will need to tighten their defense to slow down SMU’s attack and prevent a blowout.
  • Game Tempo and Turnovers: Turnover margin and how each team responds to momentum shifts will be crucial, especially since SMU has shown resilience in closely contested games.

Prediction Summary

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Considering SMU’s recent dominance over Conference USA teams and their ability to cover the spread after overtime games, they are positioned as strong favorites in this matchup. However, their historical struggles in opening road games advise some caution against expecting a runaway blowout.

Missouri State’s ability to keep the game competitive hinges on their defensive adjustments and execution on offense, but overcoming a near 28-point spread is an uphill battle.

Expect SMU to assert control early and maintain a steady performance throughout. This should result in a decisive win, though perhaps not as large as the spread anticipates.

Final Prediction

SMU to win comfortably but may not cover the full 27.5-point spread. A final score projection could be SMU 38, Missouri State 14.