Michigan State vs Indiana prediction and analysis

Matchup Overview On October 18, 2025, the Michigan State Spartans (3-3) visit the undefeated Indiana Hoosiers (6-0) in a pivotal Big Ten conference clash. Indiana enters as a heavy favorite with a -27 point spread and an over/under set at 52.5 points, reflecting their dominant form at home and Michigan State’s struggles against elite teams. […]








