Oregon vs Indiana prediction and analysis

January 13, 2026
CFB Predictions
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Matchup Overview

The Oregon Ducks and Indiana Hoosiers face off in a pivotal College Football Playoff semifinal at Mercedes-Benz Stadium in Atlanta. Both teams have had outstanding seasons and enter this game with impressive records and big-play potential. Indiana is undefeated with a 13-0 record, including a notable win over Oregon earlier in the season, while Oregon comes in at 11-1 with solid postseason form.

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Key Team Insights

  • Oregon Ducks: After starting the season strong with five consecutive wins, Oregon’s sole loss came against Indiana. The Ducks responded with an 11-1 close to the regular season and a decisive first-round playoff win against James Madison. Quarterback Dante Moore leads an efficient offense with 28 touchdown passes, ranking among the top FBS signal callers. Oregon’s strength lies in their defense, which forced four takeaways in their recent shutout victory over Texas Tech, complementing a balanced offense led by the ground game.
  • Indiana Hoosiers: The Hoosiers have powered through the season undefeated, including a recent clinical 38-3 dismantling of Alabama in the Rose Bowl. Their quarterback, Fernando Mendoza, holds the highest passer rating (130.7) among qualified players. Indiana’s defense has been suffocating, limiting Alabama’s offense to under 200 total yards and dominating third-down defense. Offensively, they combine Mendoza’s accuracy with balanced rushing, as demonstrated by Kaelon Black’s strong production.

Comparative Analysis

Indiana’s defensive prowess has been a key factor in their unbeaten run, excelling at limiting big plays and third-down conversions. Against Oregon earlier this season, the Hoosiers’ defense forced turnovers and controlled the Ducks’ offense effectively. Oregon boasts a strong second-quarter performance streak and high-scoring potential, but displayed some struggles in third-down efficiency in their recent game.

Both teams bring contrasting strengths: Oregon’s opportunistic defense and second-quarter dominance versus Indiana’s balanced attack and historically strong defensive stands at home. Indiana also has the psychological edge by having already defeated Oregon convincingly on their home turf.

Prediction Summary

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Given Indiana’s comprehensive victories over elite competition, their ability to limit Oregon’s offensive opportunities, and home-field advantage, the Hoosiers maintain the edge in this matchup. Oregon’s defensive schemes should keep the game competitive, but Indiana’s balanced attack and efficiency on third downs will likely be the deciding factors. Expect a disciplined Indiana team to execute their game plan effectively and topple Oregon once again in a closely contested game.

Final Prediction: Indiana Hoosiers to win by 7 points, leveraging their defensive toughness and offensive efficiency to secure a repeat victory over Oregon.