Ohio vs Buffalo prediction and analysis

November 26, 2025
CFB Predictions
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Overview of the Matchup

The upcoming clash between the Ohio Bobcats and the Buffalo Bulls presents an intriguing contest, particularly from a betting perspective. Ohio and Buffalo have recently followed distinct trajectories in their performances, especially in November games and at home turf, which will heavily influence the outcome.

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Key Betting Trends and Team Form

  • Ohio’s November Record: Ohio has demonstrated remarkable consistency by winning each of its last 11 November games as a favorite against teams not ranked in the AP Poll. This indicates strong mental and physical preparedness during this late-season stretch.
  • Buffalo Home Struggles: Buffalo has lost four of its last five games played at UB Stadium, highlighting vulnerability that Ohio could exploit on the road.
  • Spread Performance: Buffalo has failed to cover the spread in eight of its last nine games against non-AP-ranked teams. Conversely, Ohio has covered the spread in five of the last six matchups against Buffalo, suggesting a positive edge for bettors backing Ohio.
  • UNDER Trend: Total points have been under the set line frequently. Ohio’s last six November road games against non-AP teams have all gone UNDER, and the last four games at UB Stadium between these two teams also fell under the total. This reflects a trend toward strong defensive performances or conservative game plans.

Statistical Insights

  • Buffalo’s Defense: Buffalo ranks tied for 13th among FBS teams for first-half points allowed (8.5), showcasing a stout start defensively. However, their fourth-quarter point differential is troubling, ranking 124th with a -3.3 average, raising questions about their ability to close games.
  • Ohio’s Red Zone Efficiency: Ohio ranks 23rd in FBS in red zone defense, allowing only 77.1% efficiency, demonstrating their ability to stiffen defense where it counts most.
  • Home Field Advantage for Ohio: Ohio remains undefeated at home this season (6-0), underscoring their comfort and dominance on familiar grounds.

Prediction Summary

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Considering Ohio’s consistent November performance under favorable odds, their superior cover rate against Buffalo, and Buffalo’s recent struggles at home and on the spread, Ohio enters this matchup with an advantage. The strong defensive trends and history of low-scoring contests suggest that this will be a tightly contested game, likely decided by Ohio’s ability to execute late and capitalize on Buffalo’s fourth-quarter lapses.

Final Prediction: Ohio Bobcats to win and cover the spread in a low-scoring game, with the total points likely going UNDER the line.