Ohio vs Buffalo prediction and analysis

November 26, 2025
CFB Predictions
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Matchup Overview

The Ohio Bobcats and the Buffalo Bulls are set to face off in a key Mid-American Conference clash that carries significant betting implications. Ohio enters as a reliable favorite with a strong November performance history, while Buffalo is grappling with recent inconsistencies, especially at home. This matchup features contrasting trends in team defense, offensive execution, and overall game momentum that will heavily influence both the final outcome and betting lines.

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Key Factors to Consider

  • Ohio’s November Dominance: The Bobcats have been remarkably successful in November games when favored against unranked teams, winning their last 11 such contests. This suggests both strong preparation and a mental edge in late-season pressure games.
  • Buffalo’s Struggles at Home: The Bulls have lost four of their last five games at UB Stadium, an alarming trend for any team hoping to defend home turf. Furthermore, they have only covered the spread once in their last nine games against unranked opponents, pointing towards underperformance relative to expectations.
  • Historical Betting Trends: Ohio has covered the spread in five of the last six meetings with Buffalo, which enhances confidence in backing the Bobcats against the Bulls in this matchup.
  • Defensive Prowess vs Offensive Efficiency: Buffalo’s defense shines in the first half, ranking tied for 13th among FBS teams in limiting opponent scoring to just 8.5 points per game. However, their fourth-quarter performance is troubling, with an average point differential of -3.3, ranked very low nationally. Ohio’s offense is efficient in the red zone, converting scoring opportunities at a 77.1% clip, which indicates potential to exploit Buffalo’s late-game defensive lapses.
  • Low Scoring Game Trend: The past six November road games for Ohio against unranked teams have gone under the total points line, as have the last four Ohio-Buffalo games at UB Stadium. This trend suggests a strong likelihood of a defensive, lower-scoring game.
  • Home Field Advantage: Despite Buffalo’s recent poor home record, they remain undefeated at home this season (6-0), a statistic that can never be ignored when handicapping college football games.

Prediction Summary

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We expect a tightly contested, defensively oriented game with Ohio’s efficient red-zone offense and November resilience giving them a slight edge. Buffalo’s excellent first-half defense will keep the game close early, but fatigue and defensive breakdowns in the fourth quarter could allow Ohio to pull away late.

Given historical trends and current statistical insights, this game is likely to stay under the projected total points. Betting on Ohio to cover the spread is supported by their strong record against Buffalo and solid performance in similar November contests.

Final Prediction

Ohio Bobcats to win and cover the spread. Expect a final score margin around one possession with the total points going under.