LSU vs Ole Miss prediction and analysis

Matchup Overview
The 2025 SEC clash between LSU and Ole Miss promises to be a thrilling contest as both teams enter the game undefeated at 4-0. Scheduled for September 27 at 3:30 PM EDT, this highly-anticipated game will test the strengths of two top-tier squads in the conference. Oddsmakers have set a narrow line favoring Ole Miss by 1.5 points, with an over/under of 54.5, reflecting expectations for a competitive, high-scoring affair.
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Key Team Strengths
- Ole Miss Offensive Firepower: Ole Miss ranks seventh nationally in fourth-quarter points per game (12.3), demonstrating their ability to close out games strongly. Their offense averages 543.3 yards per game, placing them ninth among FBS teams, signaling a potent and balanced attack that can consistently move the ball.
- LSU Defensive Prowess: LSU’s defense is formidable, tied for ninth nationally in points allowed per game at just 9.3. Moreover, they are stout against the run, ranked tenth in rushing yards allowed per game (64.0), which could be critical in limiting Ole Miss’s ground game and overall offensive rhythm.
Factors to Watch
Ole Miss’s offensive productivity, especially in late quarters, could challenge LSU’s skill in maintaining leads and closing out defensively. Conversely, LSU’s defensive units, particularly against the run, may suppress some of Ole Miss’s yardage gains, forcing the Rebels to rely more heavily on their passing game.
The margin is tight, with Ole Miss’s offensive consistency slightly favored against LSU’s defensive discipline. Special teams play, turnovers, and coaching adjustments will likely be pivotal in such a finely balanced game.
Prediction Summary
This game projects to be a close thriller, with Ole Miss’s dynamic offense just edging LSU’s resilient defense. Expect a tightly contested fourth quarter given Ole Miss’s strong late-game scoring ability but also anticipate LSU making key defensive stands to keep the contest within a field-goal range.
Final Prediction: Ole Miss narrowly defeats LSU, 31-28.