Iowa State vs Arkansas State prediction and analysis

Game Overview
On September 13, 2025, Iowa State Cyclones (3-0) will travel to face the Arkansas State Red Wolves (1-1) in a non-conference showdown kicking off at 4:00 PM EDT. This matchup features a strong Iowa State squad that has started the season undefeated against a struggling Arkansas State team seeking to gain momentum early in the year.
Key Factors to Consider
- Iowa State’s Strong Current Form: The Cyclones have been exceptional, winning seven of their last eight games overall. Their consistent performance and ability to cover spreads, especially against non-conference teams where they’ve covered 4 of their last 5, indicate a well-prepared squad capable of controlling this game.
- Arkansas State’s Struggles Against Ranked Teams: The Red Wolves have a tough history when facing ranked foes, losing nine of their last ten against AP-ranked opponents. Additionally, their record as underdogs versus top-15 teams doesn’t inspire confidence, failing to cover the spread in four of five such games.
- The Challenge of a Rare Road Contest for Iowa State: Although playing away from home typically adds difficulty, Iowa State’s recent success suggests they can overcome such hurdles, especially against a team with Arkansas State’s recent form.
- Betting Lines Context: The betting odds giving Arkansas State +21 points and an over/under of 55.5 suggest bookmakers expect a comfortable Iowa State victory and moderate scoring game.
Prediction Summary
Given Iowa State’s dominant start to the season and their track record against non-conference teams, they should handle Arkansas State convincingly. The Red Wolves’ ongoing difficulties against ranked teams and inability to cover as underdogs points toward a significant challenge in this matchup. Iowa State’s balance on both offense and defense should enable them to control the pace and outcome effectively.
Final Prediction
Iowa State to win comfortably, covering the 21-point spread, with a final score projection of approximately 38-14.