Indiana vs Penn State prediction and analysis

November 7, 2025
CFB Predictions
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Matchup Overview

This Week 11 face-off features the undefeated Indiana Hoosiers traveling to challenge the Penn State Nittany Lions, a team currently struggling through a five-game losing streak. The Hoosiers, ranked second in the AP Poll and leading the nation in scoring, are aiming to extend their unbeaten run on the road against a historically dominant Penn State program.

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Key Trends and Insights

  • Historical Dominance: Penn State has consistently outperformed Indiana, winning nine of the last ten meetings. However, despite this dominance, Penn State has struggled to cover the spread in recent matchups and has had a tough November record against top-15 AP-ranked teams (losing their last 11 November games against ranked opponents).
  • Spread and Scoring Patterns: The underdog has covered the spread in eight of the last nine Indiana-Penn State games, suggesting betting value may lean toward the underdog side this week. Indiana’s offensive firepower (46.4 points per game) contrasts with Penn State’s more defensive profile, ranking 14th in passing yards allowed.
  • Strong Starts: Indiana has shown consistent early-game dominance in conference play, winning the first quarter in nine consecutive games and the first half in 14 of the last 16 conference contests. Penn State, conversely, frequently wins the first half at home but has struggled to maintain momentum throughout the game.
  • Player Impact: Kaytron Allen (Indiana) ranks tied for 13th nationally with 10 rushing touchdowns, providing a powerful ground attack. Defensively, Indiana’s Louis Moore leads the FBS with five interceptions, posing a significant threat to Paterno’s passing game. Penn State displays strength in the fourth quarter with high scoring, suggesting potential late-game rallies.
  • Offensive vs. Defensive Matchup: Indiana leads FBS in scoring and boasts the highest number of substantial home wins by double digits, emphasizing their offensive dominance. Penn State’s defense is respectable, especially in pass coverage, but may be challenged to contain Indiana’s balanced offense.
  • Betting Totals: Both teams have been involved in high-scoring affairs recently, with most games going over the total points line. Expect a shootout given Indiana’s explosive offense and Penn State’s ability to put points on the board, particularly in the fourth quarter.

Prediction Summary

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The Indiana Hoosiers enter this matchup with tremendous momentum, powered by a dynamic offense and key defensive takeaways. While Penn State has dominated historically, their recent November struggles against ranked teams and Indiana’s consistent strong starts tilt the scales in favor of the Hoosiers. Expect a high-scoring game with Indiana maintaining control from early on and Penn State’s late push falling short.

Prediction: Indiana Hoosiers win by 10 points.