Colgate vs Syracuse prediction and analysis

September 10, 2025

CFB Predictions

Matchup Overview: Colgate vs Syracuse

On September 12, 2025, Colgate (0-2) faces Syracuse (1-1) at the JMA Wireless Dome. This non-conference matchup presents a classic underdog scenario with Syracuse, a team with a strong home history, taking on Colgate, which has yet to find its rhythm this season. Expect a competitive game but one shaped heavily by home-field advantage and early season momentum.

Key Factors for Colgate

Slow Start: Colgate has stumbled out of the gate with an 0-2 record, struggling to establish consistency on offense early in games.
Opportunistic Offense: Despite the record, Colgate has shown flashes of promise, executing effective field-advancing plays such as a notable 29-yard pass to Max Walters that put pressure on opponents.
Underdog Mentality: Colgate could capitalize on Syracuse’s recent struggles covering spreads against similar non-conference opponents.

Key Factors for Syracuse

Strong Home Reputation: Syracuse has won 11 of 12 recent home non-conference games, showcasing dominance in the JMA Wireless Dome.
Success Against New York Teams: Syracuse has covered the spread in 6 of its last 7 home games when facing teams from New York state, bolstering confidence going into this matchup.
Winning Mentality: The team showed resilience in recent play, including a notable 27-20 overtime win against Connecticut where key targets like Ross-Simmons made significant impacts.

Strategic Outlook and Prediction Summary

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This game pits Colgate’s early season inconsistencies against Syracuse’s strong home field efficiency. Although Colgate has struggled out of the gate, Syracuse’s record indicates that they thrive on non-conference home games, especially against regional opponents. Syracuse’s offensive weapons and defensive discipline have proven effective in past matchups, and the team should maintain control throughout.

While Syracuse has occasionally failed to cover the spread, their consistent winning pattern at home strongly suggests a clear victory. Expect Syracuse to manage the game efficiently, exploiting Colgate’s weaknesses early and maintaining pressure throughout.

Final Prediction

Syracuse to win comfortably, potentially by a margin of 14+ points. Colgate may show moments of competitiveness but will likely be overwhelmed by Syracuse’s home advantage and overall team cohesion.