Clemson vs Boston College prediction and analysis

October 8, 2025
CFB Predictions
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Game Overview

On October 11, 2025, the Clemson Tigers (2-3) will visit the Boston College Eagles (1-4) for a pivotal ACC matchup. With Clemson favored by 14.5 points and an over/under set around 55, this game presents intriguing betting angles given both teams’ struggles so far this season. The kickoff is scheduled for 7:30 PM EDT, and fans expect a physically intense contest as Clemson looks to regain its footing and Boston College aims to avoid another loss.

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Key Factors Impacting the Game

  • Clemson’s Offensive Line Health: Clemson has faced challenges on the offensive line, but recent updates show sophomore Elyjah Thurmon remains a concern. Their offensive efficiency has fluctuated partly due to line instability.
  • Boston College’s Quarterback Play: Boston College’s QB Dylan Lonergan struggled in their last outing, completing only 9 of 18 passes for under 90 yards before being replaced. This raises concerns about the Eagles’ ability to sustain drives against a staunch Clemson defense.
  • Defensive Strengths: Clemson’s defense has been a consistent force this season, often disrupting opponents’ timing and limiting big plays. Boston College’s defense is solid but will need to step up to keep the game close at home.
  • Recent Performance Trends: Clemson has shown flashes of quality but is still recovering from a slow start. Boston College has struggled to find offensive rhythm and is searching for answers after a tough 48-7 loss at Pittsburgh.

Prediction Summary

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Considering Clemson’s overall talent advantage, stronger defense, and Boston College’s offensive struggles—especially with their quarterback situation—the Tigers should control the game tempo and dominate possession. While the Eagles will fight hard on home turf, Clemson’s experience and depth suggest a comfortable victory. The 14.5-point spread seems justified given recent performances.

Final Prediction

Clemson to win by roughly 17 points, covering the 14.5-point spread. Expect a final score near 31-14 in favor of Clemson.