Arizona State vs Iowa State prediction and analysis

October 28, 2025
CFB Predictions
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Game Overview

The November 1, 2025 matchup at 1:00 PM EDT features the Arizona State Sun Devils squaring off against the Iowa State Cyclones. Both teams enter the contest with identical 5-3 records, making this a pivotal game likely to influence their postseason trajectories.

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Iowa State Cyclones Preview

The Cyclones, favored by 5.5 points, boast a balanced team with strengths on both sides of the ball. While they have some notable injuries—several players listed out recently—it hasn’t significantly derailed their momentum. Iowa State’s offense is dynamic, capable of both explosive plays and sustained drives, and their defense has been solid in limiting opponents’ scoring opportunities. The Cyclones possess home advantage and have demonstrated resilience in close contests this season.

Arizona State Sun Devils Preview

Arizona State arrives with a similar record but has faced challenges with consistency and injuries to key contributors. Recent reports highlight questions about their depth and health, which could impact their performance against a disciplined Cyclone squad. However, the Sun Devils‘ offense has shown flashes of creativity and the potential to exploit defensive vulnerabilities. Their defense will need to step up considerably to contain Iowa State’s offensive options.

Key Factors to Watch

  • Injury Impact: Iowa State has suffered more extensive injuries but has managed to maintain form, while Arizona State’s injury situation could limit their ability to keep pace.
  • Offensive Matchups: Look for Iowa State’s balanced attack against an Arizona State defense that has struggled recently.
  • Turnover Battle: Critical aspect likely to sway momentum; teams with fewer turnovers traditionally have a better chance of pulling out the win.
  • Home Field Advantage: Playing at home favors Iowa State, who have been solid in Ames this season.

Prediction Summary

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Given the injury situations, home field advantage, and Iowa State’s more stable overall roster, the Cyclones are well-positioned to cover the 5.5 point spread. Arizona State has the talent to keep the game competitive, but they may struggle to keep up with Iowa State’s balanced offensive and defensive units.

Final Prediction: Iowa State wins by a score near 28-20, covering the spread at -5.5.