TORONTO - J.P. Arencibia hit two solo homers, Edwin Encarnacion added a three-run shot and the Toronto Blue Jays beat the Cleveland Indians 10-8 on Thursday night, avoiding their first 0-3 start since 2004.
Jose Bautista hit a two-run homer and Colby Rasmus also connected as the Blue Jays went deep five times.
Arencibia had three hits with two RBIs. He had a second-deck drive to center in the second and a tiebreaking shot to left in the sixth, his seventh career multihomer game.
Carlos Santana and Mark Reynolds replied with solo homers for the Indians, who were trying to start a season with three straight road wins for the first time since 1998.
Steve Delabar (1-0) got two outs for the win and Casey Janssen finished in the ninth for his first save.
Consecutive doubles by Jason Kipnis and Nick Swisher gave the Indians a 1-0 lead in the first, but Toronto answered in the bottom half when Bautista drilled a two-run homer to left, his second in two days.
Arencibia's leadoff drive in the second put Toronto up 3-1, but the Indians tied it in the fourth on back-to-back homers by Santana and Reynolds, whose 11th inning blast decided Wednesday's 3-2 win for the Indians.
Encarnacion lined a three-run shot that just cleared the left field wall in the fifth, putting the Blue Jays up 6-3, but Cleveland answered again in the sixth. Santana hit an RBI double and Lonnie Chisenhall chased Mark Buehrle with a two-run double to left, tying it at 6-all.
Buehrle allowed six runs and seven hits in 5 1-3 innings. He walked one and struck out four.
Arencibia broke the tie with another second deck drive to begin the bottom of the sixth, bringing Cody Allen out of the Cleveland bullpen to replace Brett Myers. One out later, Rasmus hit a solo drive to right.
Emilio Bonifacio followed with a groundball double to center, then scored on a throwing error by Reynolds, giving Toronto a 9-6 lead. Back-to-back walks loaded the bases for Adam Lind, but he flied out to end the inning.
Myers (0-1) gave up seven runs and seven hits in five-plus innings. He walked two and struck out none.
Reynolds hit an RBI single off Esmil Rogers in the seventh and Kipnis cut it to 9-8 with an RBI double off Darren Oliver in the eighth. Cleveland loaded the bases with two outs but second baseman Bonifacio ended the inning by ranging into shallow center to throw out Santana.
Toronto added an insurance run off Matt Albers in the eighth when Reyes scored from second on Bautista's fielder's choice grounder.
NOTES: Cleveland placed LHP Scott Kazmir Indians on the 15-day disabled list with a strained right ribcage muscle, retroactive to April 2. Rookie RHP Trevor Bauer is expected to start in Kazmir's place Saturday at Tampa Bay. ... Toronto's Jose Reyes was shaken up after sliding headfirst into the shin of SS Asdrubal Cabrera on a steal of second in the fifth, but stayed in the game. ... The Blue Jays host former manager John Farrell and the Boston Red Sox on Friday night. Toronto RHP Josh Johnson will start against Red Sox LHP Felix Doubront.