Anaheim, CA -- (Sports Network) - Aubrey Huff went 2-for-4 with a three-run home run, as the Baltimore Orioles hung on to edge the Los Angeles Angels of Anaheim, 6-4, in the second test of a four-game series.

Luke Scott stroked a two-run double for the Orioles, who had lost four of five coming into Friday. Nick Markakis went 2-for-4 with two runs scored and an RBI.

David Hernandez (2-2) lasted 6 2/3 innings, giving up three runs on six hits with two strikeouts and two walks to collect his second win in his fourth start in the majors. George Sherrill picked up his 18th save of the year.

"Impressive. He was throwing strikes and used all his pitches really well. He commanded his fastball and showed great poise," Orioles manager David Trembley said about Hernandez.

Kendry Morales belted a two-run homer for the Angels, who have dropped three of their last four. Maicer Izturis went 3-for-4 with a double and an RBI, while Vladimir Guerrero drove in the other run for Los Angeles, which won, 5-2, in the opener of the series on Thursday.

Ervin Santana (1-4) went five frames, allowing six runs -- four earned -- on eight hits with five strikeouts and three walks to take the loss for LA. Santana was activated from the 15-day disabled list prior to the game.

"I felt good. My location was okay, but I made a few mistakes. My arm felt good, but I just want to win," Santana said.

The Orioles drew first blood with a pair of runs in the first inning. Adam Jones was hit by a pitch, Nick Markakis reached first on Erick Aybar's fielding error, and Huff singled to load the bases with one out. Two batters later, Scott stepped to the plate and stroked a two-run double to right.

Huff blasted a three-run homer in the third to give Baltimore a 5-0 lead. Huff drove a Santana offering over the right-field wall to knock in Jones and Markakis, who had singled and doubled, respectively.

Each team scored once in the fourth, as Markakis hit an RBI single for the O's and Izturis stroked an RBI double for the Angels.

Morales blasted a two-run homer to right off Hernandez in the sixth to cut the gap to 6-3.

LA plated a run in the eighth to cut the margin to 6-4. Torii Hunter, who grounded into a fielder's choice and advanced to second and third on two wild pitches, scored on Guerrero's groundout. Jim Johnson, though, was able to get out of the inning without any further trouble.

Sherrill came on in the ninth and gave up a leadoff single to Izturis but got pinch-hitter Mike Napoli to ground into a game-ending double play.

Game Notes

The Angels lead the season series with the Orioles, 3-1. LA won the 2008 season series, 6-3...Baltimore shortstop Robert Andino had a seven-game hitting streak snapped...The Angels are 7-3 in their last 10 games.